GlucanREAL

GlucanREAL

• Major component: SC-glucan (Schizophyllan)
• Chemical structure: β-1,6-branched-β-1,3-glucan
• Origin: Schizophyllum commune (biotechnological product)
• Average molecular weight: 3.5 × 106 Da
• Content of SC-glucan: 0.5 %, 1.0%
• Characteristics: Colorless or slightly opalescence liquid

Properties

• Powerful skin moisturizing effect
• Alleviation effect for skin irritation
• Burn and Wound healing effect
• Induction of collagen biosynthesis

Applications

• Moisturizing component for general cosmetics
• Moisturizing component for cosmetics for dry skin
• Moisturizing component for cosmetics for atopic patient
• Moisturizing and Burn healing component for sun-block cream

What is SC-glucan(schizophyllan)?

• SC-glucan is a kind of β-glucan, a natural polymer produced by the fungus Schizophyllum commune consisting of a 1,3-β-D-linked backbone of glucose residues with 1,6-β-Dglucosyl side groups
  

Features

Molecular weight

Molecular weight: average 3.5X106 Da
(Korea Polymer Testing & Research Institute)

Effects on Burn and Wound Healing

SC-glucan is able to promote wound and burn healing by inducing generation of growth factors for epidermal cell proliferation. Also SC-glucan not only moisturizes but also protects wound area from microbial infections (Wasser SP, 1999).

Skin moisturizing and sedative effects

* CM value: moisture contents of skin

Immune strengthening effect

• SC-glucan is a scientifically proven biological defense modifier (BDM) that nutritionally potentates and modulates the immune response.
• SC-glucan intensified the effectiveness of the body's immune system by activating specific white blood cells called macrophage (Kikuchi M, 1980)
• SC-glucan is used as cancer treatment drugs in Japan
• SC-glucan can enhance some elements for the immune system against microbial infections (Mizuno T, 1995)

Safety

• β-1,6-branched-β-1,3-glucan was approved by the FDA in 1983 (GRAS)
• SC-glucan is clinically administered and its safety in the human body has already been confi rmed.

QueGen Biotech

• QueGen Biotech Co., Ltd. was established in 2006 for production of highly effective bio-molecules for cosmetics and health foods.
• The QueGen Biotech is equipped with microbial fermentation facilities of 10 ton scale for mass production of high functional materials using high biotechnology.
• The QueGen Biotech has several important patents. Also our R&D center is developing higher-valued biomolecules by liquid fermentation.
• The QueGen Biotech has succeeded in bio-renewable process development in cooperation with Jeju Hi-Tech Development Industry Institute.

Patents

• β-1,6-branched-1,3-glucan high-yielding strain, Schizophyllum commune QG143-1 (KR10-2007-0093013)
• Large-scale production of β-1,6-branched- β-1,3-glucan using semi-continuous fermentation performed with Schizophyllum commune (KR10-2008-0001554)
• Application of β-1, 6-branched-β-1,3-glucan from Schizophyllum commune Fr. For ingredient of ophthalmic solution (KR10-2007-0088262)